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Cancers According to non-Hodgkin Subtype

Published: 2019-07-19 |

Author: Susan Moench, PhD, PA-C |

Source: Oncology Nurse Advisor

Patients with a subtype of non-Hodgkin lymphoma (NHL) associated with an infectious etiology may be at increased risk of developing particular second solid tumor malignancies also linked to specific types of underlying infection, according to findings from a study reported in Blood Advances.

Certain infectious agents have been associated with different subtypes of NHL, such as HIV in diffuse large B cell lymphoma (DLBCL) and Burkitt lymphoma, Helicobacter pylori in gastric marginal zone lymphoma (MZL) and gastric DLCBL, hepatitis C virus (HCV) infection in DLBCL and MZL. In contrast, other forms of NHL, such as chronic lymphocytic leukemia (CLL)/small cell lymphoma (SLL) and follicular lymphoma (FL) have not shown a strong association with specific types of infection.

The aim of this retrospective study was to evaluate the risks of developing certain solid tumor second malignancies associated with an infectious etiology--eg, oropharynx/tonsil, anal, and cervical cancers, stomach cancer, and liver cancer for those with DLBCL. MZL, CLL/SLL, and FL compared with the general population.

"Whereas current guidelines from the National Comprehensive Cancer Network include recommendations for treating particular infections before starting immunosuppressive therapy/chemotherapy after NHL diagnosis, no clear recommendations exit for long-term second cancer surveillance among NHL survivors with these infections," the study authors noted.

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